LONG-READ METAGENOME-ASSEMBLED GENOMES IMPROVE IDENTIFICATION OF NOVEL COMPLETE BIOSYNTHETIC GENE CLUSTERS IN A COMPLEX MICROBIAL ACTIVATED SLUDGE ECOSYSTEM

Long-Read Metagenome-Assembled Genomes Improve Identification of Novel Complete Biosynthetic Gene Clusters in a Complex Microbial Activated Sludge Ecosystem

ABSTRACT Microorganisms produce a wide variety of secondary/specialized metabolites (SMs), the majority of which are yet to be discovered.These natural products play multiple roles in microbiomes and are important for microbial competition, communication, and success in the environment.SMs have been our major source of antibiotics and are used in a

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